Projects

Ongoing

Characterising genotype and phenotype clonal evolution of response to therapy with Artificial Intelligence

We lead a 5 years AIRC-funded MFAG project, where we use Artificial Intelligence to study clonal evolution under therapy, integrating longitudinal bulk and single-cell data of haematological cancers.

Starting year and duration: 2021 (5 years).
Fund: My First AIRC Grant, Associazione Italiana Ricerca sul Cancro (AIRC).
Team:
- Giulio Caravagna (University of Trieste). Principal Investigator.
- Luca Vago(San Raffaele Scientific Institute). Collaborator,.
- Valter Gattei (CRO National Cancer Institute). Collaborator.
- Giovanni Tonon. (San Raffaele Scientific Institute). Collaborator,.

Machine Learning algorithms for single-cell and long-reads sequencing

We lead a 2 years MUR-funded PRIN project, where we develop new machine learning algorithms for both single-cell and long-reads sequencing technologies.

Starting year and duration: 2024 (2 years).
Fund: PRIN PNRR 2022, Ministry of University and Research.
Team:
- Giulio Caravagna (University of Trieste). Principal Investigator.
- Alberto Cazzaniga (Area Science Park). Co-Principal Investigator.

The EVOverse

With the Sottoriva lab (Human Technopole) we have established a collaborative project to develop new Artificial Intelligence and population genetics methods to measure clonal evolution from cancer sequencing data.

Starting year and duration: 2022 (3 years). PI G Caravagna - A Sottoriva.
Fund: Internal.
Team:
- Giulio Caravagna (University of Trieste). Co-Principal Investigator.
- Andrea Sottoriva (Human Technopole). Co-Principal Investigator.

Completed

Single-cell cancer evolution in the clinic

We collaborate to this project to combine cancer evolution modelling, new single-cell approaches and novel microfluidic devices, as well as new data integration techniques, with the aim of providing a definitive single-cell portrait of tumor cells, before and after treatment.

Starting year and duration: 2018 (5 years).
Fund: Accelerator Award, Associazione Italiana Ricerca sul Cancro (AIRC) and Cancer Research UK.
Team:
- Giovanni Tonon. (San Raffaele Scientific Institute). Principal Investigator,.
- Andrea Sottoriva (Human Technopole). Co-Principal Investigator.
- Nicola Valeri (Imperial College). Collaborator.
- Giulio Caravagna (University of Trieste). Collaborator.
- Alex Graudenzi (University of Milan-Bicocca) Collaborator.
- Marco Antoniotti (University of Milan-Bicocca) Collaborator.

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